"It took me about twenty years before I had the right system that could be realized in practice and that scientist said it could work"
"A project for a Ph.D. student must provide him with good training and, if he is doing experimental work, there is much to be said for choosing a problem which involves the construction or modification of some fairly complicated apparatus. I have always felt that university research in engineering should be adventurous and should not mind tackling speculative projects"
"Once you add a computer between the microscope and the human observer, the whole game changes. At that point a microscope is no longer a device that has to generate a directly interpretable image. Now it's a device to record information."
"... fluorescence microscopy in its early years was considered a specialized method which, in the opinion of some, was doomed to fail. "
"You can observe a lot by watching."
"You have to be absolutely patient, but suddenly one atom was sitting right in front of the tip and I got atomic resolution. That’s the way to success, not giving up."
"every graduate student is an individual and everybody has a different way of doing science, approaching science"