"I would like to try and impress upon you while I am talking about all of these things on a small scale, the importance of improving the electron microscope by a hundred times. It is not impossible; it is not against the laws of diffraction of the electron. The wave length of the electron in such a microscope is only 1/20 of an angstrom. So it should be possible to see the individual atoms. "
From "There's Plenty of Room at the Bottom" a lecture given at American Physical Society Meeting by physicist Richard Feynman in December, 1959. In 1985 Stanford graduate student Tom Newman wrote the first page of A Tale of Two Cities on a pin head and collected the Feynman prize.
Plenty of Room at the Bottom : a Lecture by Richard P. Feldman